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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Oct 23;12(2):e1595. doi: 10.1002/wnan.1595

FIGURE 7.

FIGURE 7

(a) Scheme of degradation of dextran nanoplex and delivery of COX-2 small interfering RNA (siRNA). (b) Decrease of prostaglandin E2 (PGE2) concentration in medium following treatment of cancer cells with COX-2 siRNA/dextran nanoplex. (c) in vivo Cy5.5 fluorescence imaging showed accumulation of the dextran nanoplex in tumors. (d) Downregulation of COX-2 in tumors by COX-2 siRNA/dextran nanoplex. (Reprinted with permission from Z. H. Chen, Krishnamachary, Penet, and Bhujwalla (2018). Copyright 2018 Ivyspring International Publisher (Theranostics))