Table 1.

Lung Diseases Caused by Macrophage Dysfunction

Disease	Macrophage Dysfunction
Pulmonary Alveolar Proteinosis (PAP)	Surfactant accumulation in alveolar macrophages and alveoli
Lipoid Pneumonia	Lipid-laden macrophages and accumulation of intra-alveolar lipids
House Dust Mite + Virus-induced Asthma	Up-regulated apolipoprotein E (APOE) production by alveolar macrophages with resultant NLRP3 inflammasome activation and secretion of mature IL-1β
High-fat Diet-induced Lung Disease	Lipid-laden macrophages, increased lung cholesterol content, increased pro-inflammatory cytokines (interferon-γ, TNF and IL-6).