Table 2.
Peak Ratio of n-3 and n-6 Metabolites
| Metabolites | Total Peak Ratio | Peak Ratio at Different Times | F | P value | ||
|---|---|---|---|---|---|---|
| Baseline | 24 Weeks | 56 Weeks | ||||
| ALA | 8.94±5.51 | 5.02±3.62 | 7.86±4.26 | 13.15±5.61 | 5.02 | 0.032 |
| EPA | 32.93±51.43 | 12.15±19.74 | 39.55±34.16 | 59.44±63.51 | 32.77 | 0.001 |
| DHA | 272.1±163.7 | 246.6±128.7 | 266.7±187.6 | 323.3±157.2 | 26.05 | 0.001 |
| Stearidonic | 46.96±33.40 | 49.86±28.93 | 45.15±36.85 | 47.00±34.69 | 0.19 | 0.082 |
| Nisinic | 23.21±18.68 | 17.77±12.46 | 25.95±19.10 | 27.77±20.53 | 41.47 | 0.001 |
| DPA | 9.03±5.22 | 7.35±3.45 | 8.68±4.43 | 11.05±6.059 | 32.53 | 0.015 |
| TPA | 63.33±36.70 | 76.33±39.97 | 62.76±36.22 | 49.85±28.39 | 12.54 | 0.136 |
| THA | 6.69±5.96 | 7.08±5.57 | 7.79±7.21 | 5.89±2.79 | 16.34 | 0.078 |
| LA | 2459±2324 | 1952±859.1 | 2426±1082 | 3348±3614 | 36.59 | 0.001 |
| GLA | 463.2±309.7 | 272.1±189.4 | 434.4±172.9 | 600.7±399.1 | 38.87 | 0.001 |
| DGLA | 1.25±0.96 | 1.02±0.60 | 1.262±1.03 | 1.49±1.02 | 6.97 | 0.023 |
| ARA | 122.2±240.4 | 26.91±73.21 | 122.2±113.7 | 509.9±205.3 | 240.07 | 0.001 |
| Adrenic acid | 79.18±70.26 | 67.60±33.46 | 79.49±56.67 | 99.69±93.98 | 32.30 | 0.001 |
| Osbond acid | 45.97±41.22 | 44.80±44.78 | 48.98±40.50 | 45.7±38.58 | 0.15 | 0.804 |
| 5s-HPETE | 1.02±1.25 | 0.40±0.69 | 1.22±0.99 | 1.42±1.52 | 2.69 | 0.022 |
| 12s-HPETE | 0.45±1.09 | 0.04±0.23 | 0.69±0.74 | 1.883±1.208 | 4.81 | 0.364 |
| 15s-HPETE | 0.05±0.32 | 0.03±0.07 | 0.09±0.51 | 0.04±0.13 | 5.26 | 0.631 |
| 12s-HETE | 2.87±6.28 | 1.31±2.85 | 3.08±5.61 | 5.45±8.04 | 3.27 | 0.024 |
| 15s-HETE | 2.73±8.76 | 0.244±2.34 | 3.10±6.33 | 4.91±12.68 | 17.27 | 0.130 |
| 5s-HETE | 22.42±17.43 | 11.88±9.35 | 25.02±15.45 | 30.01±19.53 | 37.16 | 0.001 |
Abbreviations: ALA, α-linolenic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; TPA, tetracosapentaenoic acid; THA, tetracosahexaenoic acid; LA, α-linolenic acid; GLA, γ-linolenic acid; DGLA, dihomo-γ-linolenic acid; ARA, arachidonic acid; HETE, hydroxy-eicosatetraenoic acid; HPETE, hydroperoxy-eicotetraenoic acid.