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. 2020 Jul 10;15:4919–4932. doi: 10.2147/IJN.S240953

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© 2020 Liu et al.

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Scheme 1 — Schematic interpretation of W20/XD4-SPIONs in vivo. (I) W20/XD4-SPIONs penetrated the blood–brain barrier. (II) W20/XD4-SPIONs specifically detected AβOs in the brains of AD mice. (III) W20/XD4-SPIONs exhibited significant magnetic resonance signal in the brains of AD mice. (IV) W20/XD4-SPIONs promoted AβOs phagocytosis by microglia via SR-A.