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. 2020 Jan 29;45(9):1454–1462. doi: 10.1038/s41386-020-0626-y

Fig. 2. mGlu2/3 activation reduces operant responding for optical stimulation of Vglut2+ terminals in the DMS.

Fig. 2

a, b Within-subject comparisons of lever presses per session in Vglut2-Cre+/−;Ai32+/− mice (n = 7) after injection of vehicle or 3 mg/kg LY341495 (a), or vehicle or 1 or 3 mg/kg LY379268 (b). For b, * indicates a main effect of treatment session (vehicle vs. LY379268; p = 0.0031, two-way RM ANOVA). c Average lever presses per session (normalized to vehicle presses for each mouse) for each drug treatment. Bars represent mean ± SEM, and individual data points are overlaid. Doses of each drug (mg/kg) are indicated in parentheses. d, e Examples of lever presses from a representative mouse during vehicle or drug sessions. Tick marks represent individual lever presses. f–j Within-subject comparisons of patterns of pressing during vehicle or LY379268 (3 mg/kg) sessions. Parameters analyzed were clusters of pressing per session (f), mean duration of clusters (g), mean number of presses per cluster (h), mean within-cluster press rate (i), and the mean length of breaks between clusters of pressing (j). For j, *t(6) = 3.10, p = 0.0211, paired t-test.