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. 2020 Jul 14;11:3521. doi: 10.1038/s41467-020-17147-y

Fig. 10. Summary schematic of TAM-dependent MT dynamics in cancer cells.

Fig. 10

(Top) Tumor cells in vivo exhibit high MT coherence and orientation along the major length axis of elongated, migrating cells. In vitro, cancer cells display this phenotype upon co-culture with M2-like IL4-MΦ. (Bottom) The IL4-MΦ co-culture phenotype depends on cell signaling pathways in both tumor cells and MΦ, including EGFR on tumor cells, and pathways known to influence MΦ polarization including PI3Kγ and IL10R. In vivo, treatment with an IL10R-neutralizing antibody reduces MT coherence and orientation in neighboring cancer cells.