Fig. 2. Enduring effects of adolescent ketamine (KET) exposure for cocaine and sucrose preference in adult male mice.

a Twenty-one days after adolescent KET exposure (postnatal day [PD] 70+), KET-pretreated mice displayed an enhanced preference to 5 and 10 mg/kg cocaine, when compared to saline (VEH)-pretreated control mice receiving the same doses of cocaine (n = 10 per experimental group; p < 0.05). Asterisk represent within cocaine-dose group comparison (p < 0.05). Alpha represent significantly different when compared to age-matched controls conditioned to saline (p < 0.05). b No differences in distance traveled (cm) were evident during the preconditioning phase, between the experimental groups. c Adolescent KET history increased preference for a 1% sucrose solution, three weeks after KET exposure (n = 10 per group; ^Φp < 0.05). d No differences in total liquid intake were observed between the experimental groups (p > 0.05).