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. 2020 Jul 14;10:11598. doi: 10.1038/s41598-020-68179-9

Table 1.

Genes transcriptionally upregulated or downregulated in response to 0.5% (w/v) porcine bile.

Locus tag Putative Function Fold change in expression (Up regulation) P-value
Bbr_0376 Hypothetical protein 10.08 9.18E−14
Bbr_1594 PTS system fructose/glucose (fruA) 6.09 4.99E−15
Bbr_0925 Permease MFS superfamily 5.49 0.000125407
Bbr_0204 Multi-domain protein fatty acids or polyketide synthesis 4.33 1.79E−10
Bbr_1558 Permease of ABC transporter 4.16 1.98E−06
Bbr_0205 Multi-domain protein fatty acids or polyketide synthesis 3.81 2.43E−08
Bbr_0521 Solute binding protein of ABC transporter, bac 3 family 3.76 1.65E−07
Bbr_1890 ATP binding protein for ABC transporter 3.67 4.95E−09
Bbr_0492 Galactokinase 3.52 0.004216372
Bbr_0188 Formate – tetrahydrofolate ligase 3.00 0.000253137
Bbr_1719 Type I Multi-functional Fatty Acid Synthase 2.78 1.07E−07
Bbr_1615 DNA- directed RNA Polymerase Alpha Chain 2.38 5.34E−06
Bbr_1010 HIT Family Hydrolase 2.35 0.004013209
Bbr_1638 RplB, 50S ribosomal L2 protein 2.05 3.04E−05
Bbr_0183 Guanine-hypoxanthine permease 2.04 8.92E−05
Bbr_0911 IscU – Iron sulfur scaffold protein 1.93 0.000509005
Bbr_1002 Transaldolase 1.87 8.14E−07
Bbr_0499 DNA-directed RNA polymerase beta' chain 1.79 1.65E−05
Bbr_0969 Homocysteine methyltransferase 1.67 0.000468744
Bbr_0377 Oxidoreductase aldo/keto reductase family 1.63 0.003458674
Bbr_0771 Acetate kinase 1.52 0.000906418
Bbr_0329 ATP synthase beta chain 1.42 0.000860229
Bbr_0328 ATP synthase gamma chain 1.41 0.000351287
Bbr_1202 Oligopeptide transport ATP-binding protein oppD 1.28 0.001120451
Bbr_0371 Polyribonucleotide nucleotidyltransferase 1.23 0.000351287
Bbr_0776 Xylulose-5-phosphate/Fructose-6-phosphate phosphoketolase 1.13 0.00154578
Locus tag Putative function Fold change in expression (downregulation) P-value
Bbr_0579 Solute binding protein of ABC transporter system, iron siderophore, metallic cations (Zn/Mn transport) 31.39 4.25E−39
Bbr_0808 ATP-binding protein of ABC transporter system 30.33 4.51E−15
Bbr_0538 Cysteine synthase 12.64 2.48E−06
Bbr_1354 Transciptional regulator 12.16 0.004471376
Bbr_0849 NagC/XylR-type transciptional regulator 11.58 2.80E−08
Bbr_0008 Transcriptional regulator LacI family 11.01 0.002749448
Bbr_1248 Glucosamine-6-phosphate isomerase 9.41 0.000796378
Bbr_1860 Solute binding protein of ABC transporter system for sugars 9.15 0.004306336
Bbr_0083 (Filamentation induced by cAMP) Fic family protein 9.04 0.00351993
Bbr_1791 Phosphoglycerol transferase 7.13 5.68E−05
Bbr_1781 ClpB protein 6.59 3.08E−07
Bbr_1506 Cyclopropane-fatty-acyl-phospholipid synthase 5.84 2.74E−05
Bbr_1793 ATP-binding protein ABC transporter system for polysaccharides 4.55 0.000502173
Bbr_0751 Solute-binding protein of ABC transporter system for metals 4.42 0.000817759
Bbr_1590 Solute-binding protein of ABC transporter system for sugars 4.26 3.50E-08
Bbr_0106 Cellodextrin binding protein 4.17 0.000211367
Bbr_0348 Aspartate ammonia-lyase 4.06 0.005724464
Bbr_0070 Cell division protein FtsW 3.89 0.003286088
Bbr_1251 N-acetylglucosamine repressor 3.78 0.005702581
Bbr_0417 Solute-binding protein of ABC transporter system for sugars galactan metabolism 3.37 4.61E−05
Bbr_1790 Phosphoglycerol transferase 3.26 0.003699621
Bbr_0027 Permease protein of ABC transporter system for sugars 3.17 0.000263903
Bbr_0809 Permease protein of ABC transporter system 2.15 0.005541407
Bbr_1889 Cell surface protein with gram positive anchor domain 1.98 0.005000633
Bbr_0746 14-alpha-glucan branching enzyme 1.82 0.002004982
Bbr_1574 Phosphoglycerate mutase 1.79 0.00071798
Bbr_1710 Ribokinase 1.75 0.001314349

All fold changes are p < 0.05.