Table 2.
Top most differentially expressed genes in metastatic lymph nodes vs primary insulinomas. In bold genes used for validation with qRT-PCR.
| Gene | Gene symbol | Log2FC | P-value | FDR | Role |
|---|---|---|---|---|---|
| Chymotrypsinogen 2 | CTRB2 | − 8.72137 | 0.000178 | 0.033077 | Exocrine markers |
| Pancreatic lipase | PNLIP | − 8.54384 | 0.000343 | 0.04279 | |
| Pancreatic amylase | AMY2A | − 4.79146 | 0.000451 | 0.047458 | |
| Chymotrypsin-like | CTRC | − 8.86682 | 0.000427 | 0.046186 | |
| Cytocherathin 19 | KRT19 | − 8.38703 | 0.000115 | 0.027504 | Cell adhesion |
| Matrix metallopeptidase 23B | MMP23B | − 4.53596 | 0.000367 | 0.044113 | |
| Adhesion molecule with Ig like domain 2 | AMIGO2 | 5.298697 | 8.31E−05 | 0.02421 | |
| Von Willebrand factor A domain contain 5A | VWF5A | 8.34709 | 3.41E−06 | 0.026348 | |
| Serpin peptidase inhibitor, clade I, member 2 | SERPINA1 | − 8.809 | 0.00035 | 0.043207 | Serine peptidase activity |
| Serine peptidase inhibitor, Kazal type 1 | SPINK1 | − 8.55149 | 0.000344 | 0.04279 | |
| Claudin 10 | CLDN10 | − 7.19894 | 0.000195 | 0.034024 | Cell junctions |
| Claudin 19 | CLDN19 | − 7.69326 | 2.40E−05 | 0.012854 | |
| Gap junction protein beta 1 | GAPJB1 | 5.41801 | 0.000178 | 0.033077 | |
| Adhesion G protein-coupled receptor F4 | ADGRF4 | 7.871758 | 0.000116 | 0.027504 | |
| C-X-C motif chemokine receptor 5 | CXCR5 | 3.178023 | 0.000205 | 0.03415 | Inflammation |
| Chemokine (C-X-C motif) ligand 13 | CCL13 | 4.853102 | 8.30E−05 | 0.02421 |