Table 2.
Bioinformatics analysis of the effects of LAB lysates on keratinocytes.
| SGL 04 (# molecules; p value) |
SGL 07 (# molecules; p value) |
SGL 10 (# molecules; p value) |
SGL 12 (# molecules; p value) |
SGL 15 (# molecules; p value) |
SGL 19 (# molecules; p value) |
|
|---|---|---|---|---|---|---|
| Pathways (up-regulated proteins) | ||||||
| Developmental Biology | 13; 0.0021 | 12; 0.0071 | 15; 1.58e−05 | 12; 0.0059 | 12; 0.0002 | 11; 0.0041 |
| Metabolism | 24; 3.73 e−05 | 18; 0.0059 | 15; 0.0118 | 23; 8.31 e−05 | 17; 0.0002 | 16; 0.0055 |
| Metabolism of amino acids and derivatives | 8; 0.0015 | 6; 0.0290 | 9; 3.16 e−05 | 7; 0.0047 | 7; 0.00041 | 10; 4.12 e−05 |
| Metabolism of proteins | 22; 0.0001 | 19; 0.0024 | 20; 2.37 e−05 | 20; 0.0009 | 16; 0.0003 | 19; 0.0002 |
| Metabolism of RNA | 11; 0.0010 | 8; 0.0325 | 15; 5.37 e−07 | 15; 4.03 e−06 | 12; 7.37 e−06 | 12; 5.79 e−05 |
| Nonsense Mediated Decay (NMD) enhanced by EJC | 5; 0.0016 | none | 7; 6.84 e−06 | 3; 0.0327 | 7; 2.98 e−06 | 6; 8.61 e−05 |
| Nonsense Mediated Decay (NMD) independent of the EJC | 5; 0.0009 | 3; 0.0476 | 7; 4.14 e−06 | none | 7; 2.14 e−06 | 6; 5.15 e−05 |
| Peptide change elongation | 4; 0.0048 | 3; 0.0449 | 6; 1.58 e−05 | none | 6; 7.37 e−06 | 5; 0.0003 |
| Regulation of expression of SLITs and ROBOs | 7; 0.0002 | 4; 0.0410 | 8; 5.98 e−06 | 5; 0.0046 | 7; 8.67 e−06 | 7; 5.79 e−05 |
| Pathways (down-regulated proteins) | ||||||
| Apoptosis | 6; 0.0006 | 7; 0.0019 | 6; 0.0052 | 9; 0.00037 | 5; 0.0164 | 5; 0.0019 |
| Cytokine Signaling in Immune system | 7; 0.0349 | 17; 0.0003 | 13; 0.0039 | 21; 7.01 e−05 | 13; 0.0007 | 12; 0.0003 |
| Dectin-1 mediated noncanonical NF-kB signaling | 4; 0.0007 | 5; 0.0009 | 4; 0.0045 | 6; 0.0002 | 3; 0.0209 | 4; 0.0007 |
| FCERI mediated NF-kB activation | 4; 0.0015 | 6; 0.0006 | 4; 0.0096 | 6; 0.0009 | 3; 0.0310 | 4; 0.0014 |
| Hedgehog ligand biogenesis | 4; 0.0008 | 6; 0.0002 | 5; 0.0009 | 6; 0.0003 | 3; 0.0215 | 4; 0.0007 |
| Hedgehog 'on' state | 4; 0.0016 | 5; 0.0027 | 4; 0.0105 | 6; 0.0011 | 3; 0.0323 | 4; 0.0015 |
| Interleukin-1 signaling | 5; 0.0006 | 6; 0.0011 | 5; 0.0041 | 7; 0.0005 | 4; 0.0172 | 4; 0.0025 |
| Regulation of RUNX2 expression and activity | 4; 0.0010 | 5; 0.0015 | 4; 0.0067 | 6; 0.0005 | 3; 0.0251 | 4; 0.0009 |
| Regulation of RUNX3 expression and activity | 4; 0.0006 | 5; 0.0007 | 4; 0.0038 | 6; 0.0002 | 3; 0.0202 | 4; 0.0008 |
| Signaling by Interleukins | 6; 0.0200 | 13; 0.0006 | 11; 0.0023 | 16; 0.0002 | 10; 0.0017 | 9; 0.0008 |