Figure 3.

PiDose effectively administers drug to mice over a 2-month period. (a) Analysis of the temporal structure of water and drug consumption is shown at several timescales for a representative YAC128 mouse. (b) Average total water (n = 10 mice) and memantine solution (n = 6 mice) consumed per hour throughout the treatment period. Memantine solution is dispensed beginning at midnight, and animals typically consumed the required dosage by 12 PM. Mice show clear circadian rhythmicity in drinking behaviour, with most drops dispensed during the dark phase of the light cycle (grey-shaded regions). Error bars represent SEM. (c) Analysis of pictures taken immediately after drop delivery confirm that mice are properly triggering and ingesting water and drug solution on the large majority of trials.