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. 2020 Jul 14;10:11584. doi: 10.1038/s41598-020-68477-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PiDose maintains stable drug treatment despite day-to-day changes in bodyweight and water consumption. (a) Mice (n = 10) show gradual and consistent weight gain over the course of two-months of memantine treatment. Data presented as daily mean (red line) ± SEM (red-shaded region). (b) The volume of memantine solution dispensed to a representative mouse is automatically adjusted over the course of 2 months to match changes in bodyweight and ensure consistent dosage. (c) Mice (n = 10) show substantial day-to-day variability in task engagement and total consumption of drops delivered by PiDose. Data presented as daily mean (blue line) ± SEM (blue-shaded region). (d) Daily water consumption during the first week of treatment is positively correlated with daily bodyweight (n = 70), although variability is high.