Figure 2.

Comparison of ¹⁸F-florbetaben, ¹⁸F-flortaucipir SUVR and cortical volume between normosmia and hyposmia groups in all participants (a), and amyloid-β positive participants (b). Regional SUVR values were compared between the two groups after adjusting for age, sex, years of education, presence of ApoE ε4 and total cognition scores. For the comparison of regional cortical volumes between the two groups, total intracranial volume was added to the list of covariates. Data are presented as means (horizontal bars) and standard deviations (error bars) of normosmia (red) and hyposmia (blue) groups. P-values for the difference between two groups are expressed as − log₁₀ P. P-values presented with red bars indicate the regions that survived correcting for region-wise multiple comparisons (false discovery rate-corrected P < 0.05), and blue dotted lines represent uncorrected P < 0.05. Abbreviations: Aβ+ /− = Aβ-positivity, SUVR = standardized uptake value ratio, A = ¹⁸F-florbetaben SUVR, T = ¹⁸F-flortaucipir SUVR, N = cortical volume.