Table 1.

Quantification and patient data of human meningitis cases

Case Id	Age	Gender	Meningitis pathogen	Number of HIF-1α + cells		Signal
				Cortex	Leptomeninges
1	64	Male	S. pneumoniae	0	0
2	61	Male	S. pneumoniae	35	650	+++
3	88	NA	S. pneumoniae	23	30	+
4	63	Male	S. pneumoniae	150	88	++
5	24	Male	S. pneumoniae	NC	NC	++
6	71	Male	M. tuberculosis	NC	NC	++ to +++
7	67	Female	Fungi	NC	NC	++ to +++
8	72	Male	T. gondii	NC	NC	++ to +++
9	28	Female	C. neoformans	NC	NC	++ to +++

Ten areas in the cortex and five in the leptomeninges were counted for HIF-1α-positive cells from each specimen in five pneumococcal meningitis cases. The patient data for these cases and other cases of meningitis examined (supplementary Fig. 2, online resource) are included. NA indicates data not available and NC indicates not counted. For some cases, the staining signal was weak (indicated by +). Cause of death for all the patients from (1–8) was meningitis, but for patient 9 it is not available