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. 2020 Jul 8;11:371. doi: 10.3389/fendo.2020.00371

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Copyright © 2020 Madan and Celi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tradeoffs in study design of LT3:LT4 combination therapy or DTE vs. LT4 alone for the treatment of hypothyroidism. Tradeoffs in four domains of a clinical trial directed to assess the efficacy and effectiveness of therapies other than LT4 alone vs. LT4. The left part of the panels (red) indicates choices more suitable for a patient-centered study, while the right side of the panels indicates choices more suitable for a data-focused study.