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. 2020 Jul 8;11:551. doi: 10.3389/fneur.2020.00551

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Copyright © 2020 Li, Dong, Liu, Zou, Hao, Gao, Pan and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of nigericin, NEK7 small interfering RNA pretreatment, and MCC950 treatment on NLRP3 activation and apoptosis related protein expression. (A,K) Representative western blot bands of NLRP3, NEK7, ASC, caspase-1, and IL-1β from the ipsilateral cortex after SAH. (B–G, L–Q) Quantitative analysis of NLRP3, ASC, pro-caspase-1, caspase-1 p20, NEK7 and IL-1β, n = 6. (H,R) Representative western blot bands of BCL-2 and BAX. (I,J,S,T) Quantitative analysis of BCL-2 and BAX. Relative densities of each protein have been normalized to the sham group, n = 6. *: vs. sham P < 0.05, &: vs. SAH+Vehicle P < 0.05, and #: vs. SAH+nigericin+Scr siRNA P < 0.05.