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. 2020 Jul 8;8:549. doi: 10.3389/fcell.2020.00549

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Copyright © 2020 Lefebvre, Rybarczyk, Bretaudeau, Vanlaeys, Cousin, Brassart-Pasco, Chatelain, Dhennin-Duthille, Ouadid-Ahidouch, Brassart and Gautier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EDPs enhance MIA PaCa-2 migration through TRPM7 expression. (A) Effect of 24 h incubation with 10^–7 M AG-9 and VG-6 EDPs on the MIA PaCa-2 cell migration assessed by Boyden chamber assay. (B) Effect of EDPs on cell viability assessed by MTT assay. (C) Effect of TRPM7 silencing on AG-9 enhanced cell migration. (D) Effect of TRPM7 silencing and AG-9 treatment on cell viability. (E) Effect of TRPM7 silencing on VG-6 enhanced cell migration. (F) Effect of TRPM7 silencing and VG-6 treatment on cell viability. All results are shown as means ± SEM. *P < 0.05; ***P < 0.001 by ANOVA followed by post hoc Dunn’s tests.