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. 2020 Jul 8;8:549. doi: 10.3389/fcell.2020.00549

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Copyright © 2020 Lefebvre, Rybarczyk, Bretaudeau, Vanlaeys, Cousin, Brassart-Pasco, Chatelain, Dhennin-Duthille, Ouadid-Ahidouch, Brassart and Gautier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RPSA expression in human PDAC. (A) RPSA is ubiquitously expressed in the normal pancreatic tissue (pancreatic duct and acinar cells, inflammatory, and stromal cells) but no unspecific staining was seen in collagen fibers, black arrows focus on healthy pancreatic ducts. (B) At high magnification, a weak and cytosolic staining was observed in normal duct cells. (C) In PDAC tissue, a high staining was observed in all tumoral cells, and black stars show tumoral glandular structures. (D) At high magnification, a high and cytosolic staining was always observed in tumoral cells. Inserts: RPSA staining was not apparent in the absence of the primary antibody.