TABLE 4.

Overview of anti-TGF-β therapies based on kinase inhibitors used in cancer clinical trials.

Drug (target)	Clinical trial (phase)	Status	Cancer type	Patients enrolled	Arms	Outcomes
LY2157299 (TβRI)	NCT01220271 (Phases I/II)	Completed	Glioma	75	Phase I LY2157299 (160 mg) + radiotherapy + temozolamide LY2157299 (300 mg) + radiotherapy + temozolamide Phase II LY2157299 (established dose) + radiotherapy + temozolamide Radiotherapy + temozolamide	NA
LY3200882 (TβRI)	NCT02937272 (Phase I)	Active, not recruiting	Solid tumors	223	LY3200882 LY3200882 + LY3300054 LY3200882 + gemcitabine + nab-paclitaxel LY3200882 + cisplatin + radiation	NA
LY3200882 (TβRI)	NCT04031872 (Phases I/II)	Active, not recruiting	Colorectal metastatic cancer	31	Single-arm: LY3200882 + capecitabine	NA

Cmax, maximum concentration; ORR, objective response rate; PFS, progression-free survival; CBR, clinical benefit rate; CR, complete response; PR, partial response; AUC, area under the curve; SAE, serious adverse event; OS, overall survival; NA, not available.