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. 2020 Jul 8;10:313. doi: 10.3389/fcimb.2020.00313

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Copyright © 2020 Ivanova, Krempels, Denton, Fettel, Saltz, Rach, Fatima, Mundhenke, Materi, Dunay and Gigley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NK cells do not exhibit immune exhaustion characteristics during chronic T. gondii infection. C57BL/6 mice were orally infected or not with 10 cysts of ME49 and 5 and 7 weeks after infection spleen cells were analyzed for (A) NK cell (Lineage-CD49b+) frequency and number. NK cells, CD4+ and CD8+ T cells were then analyzed for (B) PD1 MFI and (C) PD1+ frequency based on separating the populations into PD1 low (Lo), intermediate (Int), and high (Hi). NK cells were then assayed for (D) LAG3 expression. Raw flow data presented are representative and based on means from 3 independent experiments. All graphs are mean ± SD. Graphs present pooled data from 2 independent experiments. Significance is denoted by ^*with a p ≤ 0.05, n = 4–5 mice per group.