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. 2020 Jul 8;10:313. doi: 10.3389/fcimb.2020.00313

Figure 2.

Figure 2

NK cells promote immune exhaustion and parasite reactivation during chronic T. gondii infection. C57BL/6 mice were infected orally with 10 cysts of ME49 and infection outcome monitored. (A) Survival after 200 μg anti-NK1.1 or 200 μl 1 X PBS every 2nd day starting at week 5 p.i. Graph presents pooled data from 3 independent experiments, n = 4–5 mice per group (B) Brain cyst burden after anti-NK1.1 or 1 X PBS treatment starting at week 5 p.i. Graph presents data from 1 experiment repeated independently 2 times with n = 5 mice per group. (C) Survival of chronically infected animals after lethal secondary 200 ME49 cyst or 1,000 tachyzoite RH strain challenge with or without anti-NK1.1 treatment. Experiments were repeated independently 2 times with n = 4–5 mice per group. All graphs are mean ± SD. *denotes significance as p ≤ 0.05.