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. 2020 Jul 8;11:1550. doi: 10.3389/fmicb.2020.01550

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Copyright © 2020 Zhang, Gu, You, Xu, Zhou, Chen, Yan, Jiang, Li, Lv and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction of ITP-enriched bacteria and metabolites. (A) Receiver-operating characteristic (ROC) plot for Streptococcus, Streptococcus anginosus and Streptococcus salivarius, areas under the parametric curve (AUC) value are 0.875, 0.880, and 0.856, respectively. (B) ROC plot for Cer (t18:0/16:0), Cer (d18:1/17:0), and PI [20:1(11Z)/22:4(7Z,10Z,13Z,16Z)], AUC are 0.861, 0.874, and 0.850, respectively. (C,D) The ROC analysis of the combination of Weissella and Streptococcus anginosus, or Cer (t18:0/16:0), Cer (d18:1/17:0), and 13-hydroxyoctadecanoic acid, with their corresponding AUC reaching 0.948 and 0.984, respectively.