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. 2020 Jul 8;11:1550. doi: 10.3389/fmicb.2020.01550

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Copyright © 2020 Zhang, Gu, You, Xu, Zhou, Chen, Yan, Jiang, Li, Lv and Qian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations between altered gut microbiome, metabolites, and hematological variables in ITP. (A) Association of ITP-altered fecal bacteria, metabolites with hematological variables. (B) The association of ITP-altered fecal bacteria with metabolites. Correlation coefficients (in absolute value) higher than 0.4 and p < 0.0001 were used as significance thresholds. (C) The association of ITP-altered gut microbiota and metabolites and platelet count. The pink color, light green, and orange represent bacteria, metabolites, and platelet count, respectively. Blue line represents negative correlation, while red line represents positive correlation.