Figure 1.

A 60-year-old woman with moderately differentiated rectal cancer. (A) T2-weighted image shows a clear delineation of the tumor. (B) Multiple regions of interest (ROIs) of 13–20 mm² were placed within the mass lesion on ADC map, and ADC values were obtained as follows: minimum ADC, 0.368 × 10⁻³ mm²/s; maximum ADC, 1.235 × 10⁻³ mm²/s; ADC difference value, 0.867 × 10⁻³ mm²/s; average ADC, 0.654 × 10⁻³ mm²/s. (C) Photomicrograph of histologic specimen shows intratumoral heterogeneity in which high- and low cell density areas coexist and marked interstitial fibrosis (single asterisk) (original magnification × 40; hematoxylin–eosin [H–E] stain). (D) Photomicrograph of histologic specimen shows many lymphocytes, plasmacytes, and neutrophils in the interstitial space of cancer glands (original magnification × 400; HE stain).