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. 2020 Jul 14;11:3516. doi: 10.1038/s41467-020-17091-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IHC analysis of IRSp53 expression and localization in the indicated human tissues and organs. Arrowheads indicate the apical/luminal enrichment of IRSp53. Scale bar, 50 µm. b IF analysis of human kidney. Samples were stained with anti-IRSp53 (red), anti-Laminin (green) and DAPI (upper panels) or with anti-IRSp53 (red) anti-ZO-1 (green) and DAPI (lower panels). Arrowheads and arrows indicate the apical/luminal localization of IRSp53 and ZO-1, or the basal enrichment of Laminin, respectively. Scale bar, 50 µm. c IHC analysis of the expression and localization of IRSp53 in the indicated murine tissues and organs. Arrowheads indicate the apical/luminal enrichment of IRSp53. Scale bar, 20 µm. d IHC analysis of Baiap2a and Baiap2b expression and localization in zebrafish embryo (Inset: PD) at 72 hpf in the indicated genetic backgrounds: baiap2a wild-type (b2a WT), baiap2a mutant (b2a −/−), baiap2b morphant (b2a WT b2b_Mo) and baiap2a mutant baiap2b morphant (b2a −/− b2b_Mo). Arrowheads indicate the apical/luminal enrichment of IRSp53 in the pronephric duct. Scale bar, 50 µm (insets, 200 µm).