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. 2020 Jul 14;11:3516. doi: 10.1038/s41467-020-17091-x

Fig. 9. Genetic removal of IRSp53 leads to defects in murine kidney morphology.

Fig. 9

a Hematoxylin and eosin staining of kidneys explanted from wild-type (WT) and IRSp53-KO adult mice were fixed, processed and paraffin embedded. Left: Low magnification images. Right: magnified images of the red (tubular phenotype) and blue (glomerular phenotype) boxes on the left. Black arrowheads, abnormal irregular distributions and shapes of the nuclei in the IRSp53-KO kidneys; yellow ellipses, areas with disarrayed and convoluted tubules; yellow arrowheads, glomerular tuft microcystic alterations. Scale bar, 50 µm. b Quantification of the renal alteration score. Kidneys from wild-type (WT) and IRSp53-KO mice were analyzed and scored for defects in renal morphology (see also Fig. S9B and Methods). Data are means ± SD. WT, n = 8 (4 M, 4 F); KO, n = 16 (6 M, 10 F). P value, student’s t-test two-tailed. ***p < 0.001. Source data are provided in Supplementary Fig. 10 B and as a Source Data file.