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. 2020 Jul 14;11:3515. doi: 10.1038/s41467-020-17083-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Domain-specific biomarkers identified by the spatial-domain networks are used to interrogate the KEGG and STRING databases to identify domain-specific pathways enriched by the biomarkers. The epithelial, stromal, and epithelial-stromal domain are, respectively, shown in green, red, and blue, with pathways unique to those domains also coded with the same colors. Pathways that are enriched in more than one domain are coded with a color combination of those respective domains. For example, the PI3K-AKT signaling pathway is enriched in all three spatial domains, and therefore, has a boundary box color-coded with all three colors. On the other hand, the mismatch repair pathway is enriched in the epithelial and epithelial-stromal domains, and is therefore, color-coded by red and blue colors.