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. 2020 Jul 14;11:3520. doi: 10.1038/s41467-020-17064-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Survival curve of PRDM15^+/+Rosa26;CreER (n = 13) or PRDM15^F/F;Rosa26;CreER (n = 14) mice that were injected with Tamoxifen (TAM) at 8 weeks of age (Prdm15^∆/∆). b Bone marrow cellularity and white blood (WBC) cell counts of PRDM15+/+ and PRDM15∆/∆ mice 2 months after tamoxifen injection (n = 4). Center values, mean; error bars, s.d. Student’s t test (two-sided) was used for statistical analysis. c Survival rate of mice that were lethally irradiated and then reconstituted with cells derived from mice with the indicated genotypes (n = 5 for each group). In black, the non-reconstituted control. d Representative histology images showing H&E staining of various organs from PRDM15^+/+ and PRDM15^∆/∆ mice 2 months after tamoxifen injection (scale is 100 μm). In panels a and d, log-rank test was used to determine statistical significance.