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A proposed signaling pathway involved in SeMet against ESBL E. coli-induced inflammation. Note that SeMet protects bMECs and macrophages against inflammation by inhibition of TLR4/NF-κB signaling pathway. Meanwhile, SeMet suppressed NF-κB pathway through SeS and inhibited NF-κB-reduced inflammation. Green arrow and red bar indicate stimulation and inhibition, respectively.
