Figure 2.

Dectin-1 signaling is required to control fungal infection and prevent invasive aspergillosis. Wild-type C57BL/6 or dectin-1^−/− mice were infected with 8 × 10⁷ live CEA10 conidia then monitored for survival for 10 days. (A) Kaplan-Meir survival plot for 10 mice per group analyzed in two independent experiments. (B,C) Histological samples showing representative GMS staining of dectin-1^−/− and wild-type mice lung sections. (D) Pulmonary fungal burden at 48 h after infection in dectin-1^−/− and control wild type mice. Data is cumulative of two independent experiments. For CFUs, each symbol represents one mouse. Each survival experiment was performed twice with five mice per group for a total of 10 mice per group. (A) ***P < 0.001 as determined by log-rank (Mantel-Cox) test. (D) ****P < 0.0001, calculated by Mann-Whitney non-parametric test.