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. 2020 Jul 8;11:1430. doi: 10.3389/fimmu.2020.01430

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Copyright © 2020 Abraham, Botto, Mizuno, Pryke, Gall, Boehm, Sali, Jin, Nilsen, Gough, Baird, Chakhtoura, Subra, Trautmann, Haddad and DeFilippis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M04 Induces Canonical STING Activation. (A) lmmunoblot showing phosphorylation status of STING Ser366 as well as total STING in THF and MM6 following 4 h treatment with 1% DMSO, 50μM M04, 1,000 HAU/mL SeV or 25 μM ABZI as indicated; (B) Indirect immunofluorescence showing subcellular localization of Golgi marker GM130 and STING in THF exposed for 4 h to DMSO, transfected cGAMP (10 μg/mL), 100 ng/mL TNFα, or 50 μM M04; (C) Melting temperature shifts for human STING-CTD in the presence of DMSO, 75 μM M04, or 100 μM 2'3' cGAMP. Data presented are SYPRO orange relative fluorescent units (RFU).