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. 2020 Jul 8;11:991. doi: 10.3389/fphar.2020.00991

Figure 2.

Figure 2

Architecture of chicken ASIC1a channel (PDB code 4NYK). (A, B) Side-views of the channel. Two channel subunits are shown by wheat and pale green colors, and the third subunit is colored according its domain structure: the knuckle, finger, b-ball, thumb, palm, and TM part are colored in yellow, dark red, light green, purple, blue, and orange, respectively. Asp and Glu residues forming the acidic pockets (surrounded by black dashed circles) and GAS belts are shown by spheres. The locations of the β1-β2 and β11-β12 linkers are colored by red. (C) Top view of the channel. (D) View of the channel from an intracellular side. The ion selectivity filter formed by three GAS belts is shown by a red dashed circle. (E) Comparison of the residues forming the acidic pocket and TM2 in ASICs of different origin (cASIC1, chicken ASIC1; rASIC1, rat ASIC1; lASIC, lamprey ASIC1; hASIC1,2,3, human ASIC1,2,3).