Table 1.
Influence of the 7-day intravenous administration of O-1602 (0.25 mg/kg/day) on the cystometric parameters in conscious rats subjected to corticosterone therapy.
| Substances | amplitude of nonvoiding contractions [cm H2O] | area under the pressure curve [cm H2O/sec] | bladder compliance [ml/cm H2O] | basal pressure [cm H2O] | detrusor overactive index [cm H2O/ml] | frequency of nonvoiding contractions [times/filling phase] | intercontraction interval [s] | micturition voiding pressure [cm H2O] | postvoid residual [ml] | threshold pressure [cm H2O] | volume threshold to elicit nonvoiding contractions [%] | voided volume [ml] |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| vehicle (14 days) + vehicle (7 days) |
2.540 ± 0.0809 | 20.27 ± 0.6864 | 0.3093 ± 0.0116 | 3.433 ± 0.1511 | 60.27 ± 3.073 | 0.8587 ± 0.0488 | 1065 ± 26.39 | 48.53 ± 1.316 | 0.075 ± 0.0023 | 8.907 ± 0.2579 | 73.93 ± 1.958 | 0.9713 ± 0.03747 |
| CORT (14 days) + vehicle (7 days) |
6.313 ± 0.1527*** | 31.20 ± 0.8685*** | 0.2420 ± 0.0125*** | 4.760 ± 0.3000*** | 364.6 ± 19.05*** | 7.240 ± 0.2903*** | 851.5 ± 27.59*** | 44.13 ± 1.983 | 0.069 ± 0.0033 | 6.647 ± 0.2855*** | 54.67 ± 2.142*** | 0.7953 ± 0.03217** |
| vehicle (14 days) + O-1602 (7 days) |
2.613 ± 0.1125 | 18.07 ± 0.6208 | 0.2767 ± 0.0057 | 2.827 ± 0.1637 | 57.47 ± 3.830 | 1.041 ± 0.1032 | 1080 ± 27.43 | 52.20 ± 1.964 | 0.089 ± 0.0029* | 9.127 ± 0.4546 | 66.87 ± 2.799 | 0.9347 ± 0.03066 |
| CORT (14 days) + O-1602 (7 days) |
3.327 ± 0.1596***^^^ | 22.07 ± 0.6360^^^ | 0.3360 ± 0.0123^^^ | 2.840 ± 0.1809^^^ | 140.5 ± 7.994***^^^ | 3.680 ± 0.2649***^^^ | 999.2 ± 34.14^^ | 40.13 ± 2.122** | 0.090 ± 0.0046**^^^ | 4.900 ± 0.2719***^^^ | 67.87 ± 2.201^^^ | 1.045 ± 0.04691^^^ |
Corticosterone (CORT, 20 mg/kg/day) was given subcutaneously for 14 days and O-1602 (0.25 mg/kg/day) was administered intravenously for 7-days. The values represent the mean ± SEM (n = 15 rats per group). The obtained data were assessed by the two-way analysis of variance (ANOVA) followed by Bonferroni’s post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001 versus saline, ^^p < 0.01, ^^^p < 0.001 versus CORT.