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. 2020 Jun;20(2):122–130. doi: 10.2174/1871529X19666190912152041

Fig. (5).

Fig. (5)

Effects of substance P (SP) on cardiac function of mice with ischemia and reperfusion injury. The hearts from wild type (WT) and TRPV1-/- mice fed control diet (CD) or high-fat diet (HFD) for 20 weeks were retrogradely perfused in a Langendorff apparatus. SP was perfused 10 min before cardiac ischemia and reperfusion injury. Coronary flow (CF, a), left ventricular peak positive dP/dt (+dP/dt, b), left ventricular developed pressure (LVDP, c), and left ventricular end-diastolic pressure (LVEDP, d) were measured. Values are mean ± SEM of 6-8 mice. For the left parts of each panel, *P<0.05 vs. WT-CD; †P<0.05 vs. TRPV1-/--CD; ‡P<0.05 vs. WT-CD-SP. For the right parts of each panel, *P<0.05 vs. WT-HFD; †P<0.05 vs. TRPV1-/--HFD; ‡P<0.05 vs. WT-HFD-SP. (A higher resolution / colour version of this figure is available in the electronic copy of the article).