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Histidine and AICAR production by Buchnera predicted from flux balance analysis of the Hamiltonella-free model comprising Buchnera and the aphid, and three-compartment models with increasing biomass of Hamiltonella. (A) AICAR overflow. (B) Flux through HisD reaction, as an index of total histidine production. Values corresponding to the empirically determined Buchnera/Hamiltonella ratio are indicated by a black bar and black circle.
