Figure 1.

Energy metabolism in cancer cells and cancer stem cells. HK: Hexokinase; G-6-P: Glucose-6-phosphate; PFK1: 6-phosphofructo-1-kinase; PEP: Phosphoenolpyruvate; PK: Pyruvate kinases; PDC: Pyruvate dehydrogenase complex; LDH: Lactate dehydrogenase; PDK: Pyruvate dehydrogenase kinase family; TCA: Tricarboxylic acid; CAFs: Cancer associated fibroblasts; ECs: Endothelial cells; PDGF: Platelet-derived growth factor; HIF: Hypoxia inducible factor; TME: Tumor microenvironment; OXPHOS: Oxidative phosphorylation.