Table 3.

Association between DQB1*05:02–DRB1*16:02 haplotype and clinical features in paediatric-onset patients with MOGADs

	Patients with haplotype n=10	Controls n=41	P value
Age, years, median (range)	11 (3–16)	10 (3–18)	–
Age of onset, years, median (range)	4 (2–14)	8 (2–13)	–
Inducement, n (%)
Previous infection	3 (30)	15 (38)	0.730
Phenotype at onset, n (%)*
ON	5 (50)	20 (49)	>0.999
Myelitis	2 (20)	2 (5)	0.168
Encephalopathy	5 (50)	21 (51)	>0.999
Brainstem syndrome	0	4 (10)	0.573
Others	0	3 (7)	>0.999
Initial EDSS, median (range)	4.25 (2–8)	3 (1–6.5)	0.004
Baseline titre, median (range)	320 (100–640)	100 (100–1280)	0.387
Patients with relapse, n (%)	8 (80)	15 (37)	0.030
Relapse type, n (%)*
ON	9/16 (56)	10/31 (32)	0.131
Myelitis	2/16 (13)	2/31 (7)	0.597
Encephalopathy	6/16 (38)	18/31 (58)	0.227
Brainstem syndrome	0	4/31 (13)	0.284

*Patients may exhibit multiple phenotypes simultaneously.

EDSS, Expanded Disability Status Scale; MOGADs, myelin oligodendrocyte glycoprotein-associated disorders; ON, optic neuritis.