Table 5.

Time to mortality

	Non-carriers	All GBA1 variants	Non-pathogenic variants	Pathogenic mutations
Number	214	48	25	17
Estimated mean time to death (years)	10.6 (10.0 to 11.3)	9.4 (8.4 to 10.5)	10.0 (8.7 to 11.3)	9.5 (7.8 to 11.3)
Estimated median time to death (years)	10.0 (9.3 to 10.7)	9.4 (8.3 to 10.6)	10.0 (8.9 to 11.1)	8.5 (7.7 to 9.3)
5-year survival (%)	89.2 (SE 2.2)	93.4 (SE 3.7)	96.0 (SE 3.9)	100.0
10-year survival (%)	49.6 (SE 3.9)	39.8 (SE 8.8)	49.7 (SE 11.6)	29.8 (SE 14.1)
15-year survival (%)	20.1 (SE 3.9)	5.3 (SE 5.0)	7.8 (SE 7.3)	0
Log-rank p value	–	0.169	0.639	0.275
HR	–	1.5 (1.0 to 2.3; p=0.061)	1.2 (0.7 to 2.0; p=0.567)	2.1 (1.0 to 4.1; p=0.043)

Long-term follow-up data for progression to time to mortality in PD patients without GBA1 variants compared with those carrying any GBA1 variant, a pathogenic GBA1 mutation or a GBA1 ‘non-pathogenic’ variant.

HR determined by Cox regression analysis controlling for age at diagnosis and sex. Ninety-five per cent CI for HR and estimated mean and median shown in brackets. Log-rank p values shown for comparison between the GBA1 groups and the non-carrier group. Statistically significant results highlighted in bold.

PD, Parkinson’s disease.