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. 2020 Mar 22;75(7):576–583. doi: 10.1136/thoraxjnl-2018-213021

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Study design and classification of study participants. In model establishment and test cohort, a total of 403 individuals were prospectively evaluated. Thirty-five individuals were excluded due to invalid culture or lack of clinical data. Of the 368 subjects, 276 (87 TB, 68 HC, 54 LTBI and 67 PN) were used as a training set to establish the diagnostic model and 92 subjects (29 TB, 16 HC, 30 LTBI and 17 PN) were used as a test set to validate the diagnostic model. In prediction cohort, 111 individuals were prospectively recruited. Nine cases were excluded and 102 individuals (32 TB, 19 HC, 27 LTBI and 24 PN) thus remained for further analysis. CXR, chest X-ray; HC, healthy control; IGRAs, interferon-γ release assays; LTBI, latent tuberculosis infection; PN, pneumonia; ROC, receiver operator characteristic.