Table 4.

Diagnostic accuracy of the eight-protein biosignature in diagnosing TB

Model	Group	Clinical diagnosis (n)	Classified as non-TB (n)	Classified as TB (n)	Cut-off value	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	Accuracy (95% CI)
Training (n=276)	Non-TB	189	189	0	0.4	100% (96% to 100%)	100% (98% to 100%)	100% (98% to 100%)	100% (96% to 100%)	100% (99% to 100%)
	TB	87	0	87
Test (n=92)	Non-TB	63	52	11	0.4	76% (56% to 90%)	83% (71% to 91%)	88% (77% to 95%)	67% (48% to 82%)	80% (71% to 88%)
	TB	29	7	22
Prediction (n=102)	Non-TB	70	59	11	0.4	75% (57% to 89%)	84% (74% to 92%)	88% (78% to 95%)	69% (51% to 83%)	81% (72% to 88%)
	TB	32	8	24

NPV, negative predictive value; PPV, positive predictive value.