Table 4.

Canonical pathways altered in septic lungs treated with MSCs

Pathways	Combined score	Database
Induction of apoptosis via DR3 and DR4/5 death receptors	9.14	BioCarta
Salmonella infection	8.42	KEGG
Apoptosis modulation by HSP70	7.29	Reactome
FAS pathway and stress induction of HSP regulation	6.64	Reactome
Glycosphingolipid biosynthesis	6.36	KEGG
Wnt signalling pathway netpath	6.26	Reactome
Adipocytokine signalling pathway	6.25	KEGG
BDNF signalling pathway	6.14	Reactome
FAS signalling pathway	5.99	Panther
Neurotrophin signalling pathway	5.66	KEGG
ER-associated degradation pathway	5.40	BioCarta
Signal transduction of S1P receptor	5.06	Reactome
FAS signalling pathway (CD95)	5.03	BioCarta
AMPK signalling pathway	5.03	KEGG
Insulin signalling	4.72	Reactome
Fc gamma R-mediated phagocytosis	4.08	KEGG
mRNA surveillance pathway	4.02	KEGG
Nicotinic acetylcholine receptor signalling pathway	3.90	Panther
Cytoskeletal regulation by Rho GTPase	2.98	Panther
Nerve growth factor pathway	2.70	BioCarta
Huntington disease	2.42	Panther
CXCR4 signalling pathway	2.39	BioCarta
Apoptotic signalling in response to DNA damage	1.94	BioCarta
EGF signalling pathway	1.86	BioCarta
JAK/STAT signalling pathway	1.75	Panther
5HT3 type receptor-mediated signalling pathway	1.32	Panther
Muscarinic acetylcholine receptor 1 and 3 signalling pathway	1.21	Panther
5HT2 type receptor-mediated signalling pathway	1.13	Panther
5HT4 type receptor-mediated signalling pathway	1.06	Panther
p53 pathway	0.51	KEGG
Inflammation mediated by chemokine and cytokine signalling	0.03	Panther
Parkinson disease	−0.40	Panther
Epinephrine and norepinephrine biosynthesis	−0.45	KEGG
Alzheimer disease-amyloid secretase pathway	−0.62	Panther

EGF, epidermal growth factor ; HSP70, heat shock protein 70; MSC, mesenchymal stromal cell.