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. 2020 Apr 30;75(7):606–608. doi: 10.1136/thoraxjnl-2019-214238

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Bacteriological response to treatment measured by the TB-MBLA (A) and by MGIT (B) at four study sites. The curves indicate the average bacillary load reduction mirroring increase in culture time-to-positivity by all patients over a 12-week treatment period. Dots represent individual patients at each site. Data points are widely spread in culture, which imply high culture result variability in late stages of treatment. Black curves with thick black dots represent clinical trial site 1 and 2 cases. Red curves and red diamond clear symbols represent site 3 cases and blue curves with black clear dots represent site 4 cases (MGIT culture stopped at week 8). MGIT, mycobacterial growth indicator tube; TB-MBLA, tuberculosis molecular bacterial load assay.