Table 3.
Univariate analysis of predictors of abnormal DLCO% predicted.
| Parameters | Normal range | DLCO normal group (n = 46) | DLCO impaired group (n = 9) | P value |
|---|---|---|---|---|
| Age, years | ≥ 18 | 44.99 ± 14.70 | 52.57 ± 18.91 | 0.095 |
| Sex, (% female) | 19 (41.30%) | 4 (44.44%) | 0.861 | |
| Incubation period, d | 6.00 (4.00–7.25) | 6.00 (4.50–7.50) | 0.503 | |
| Temperature, °C | 37.80 (36.70–38.43) | 38.00 (37.60–38.35) | 0.600 | |
| CXR peak score | 7.22 ± 4.66 | 8.06 ± 5.82 | 0.638 | |
| Comorbidities | ||||
| Hypertension | 5 (10.87%) | 1 (11.11%) | 0.983 | |
| Coronary heart disease | 2 (4.35%) | 0 (0%) | 1.000 | |
| Diabetes mellitus | 1 (2.17%) | 1 (11.11%) | 0.737 | |
| Signs and symptoms at admission | ||||
| Fever | 28 (60.87%) | 9 (100%) | 0.057 | |
| Cough | 22 (47.83%) | 8 (88.89%) | 0.058 | |
| Feeble | 18 (39.13%) | 0 (0%) | 0.057 | |
| Laboratory data | ||||
| Blood Routine | ||||
| Leucocyte count (× 109/L) | 4–10 | 5.62 ± 1.75 | 5.81 ± 2.50 | 0.774 |
| Neutrophil count(× 109/L) | 2–7 | 3.74 ± 1.48 | 4.11 ± 2.63 | 0.556 |
| Lymphocyte count (× 109/L) | 0.8–4.0 | 1.42 (1.08–1.73) | 1.22 (0.98–1.87) | 0.601 |
| NLR | 2.79 (1.89–3.66) | 2.11 (1.73–4.46) | 0.716 | |
| Hemoglobin concentration (g/L) | 110–160 | 143.59 ± 18.73 | 130.00 ± 24.44 | 0.064 |
| Platelet count (× 1012/L) | 100–300 | 175.67 ± 55.40 | 179.89 ± 75.67 | 0.845 |
| Blood Biochemistry | ||||
| ALT, U/L | 0–40 | 24.90 ± 7.42 | 31.63 ± 12.30 | 0.146 |
| AST, U/L | 0–40 | 20.45 (13.98–30.10) | 21.30 (11.50–38.90) | 0.991 |
| Albumin, g/L | 40–53 | 43.03 ± 3.66 | 40.38 ± 3.12 | 0.047 |
| TP, g/L | 64–83 | 65.12 ± 4.92 | 63.39 ± 6.49 | 0.518 |
| GGT, U/L | 7–50 | 20.60 (15.05–38.13) | 25.90 (16.00–52.35) | 0.460 |
| Total bilirubin, μmol/L | 3.42–20.50 | 8.90 (7.28–13.38) | 13.20 (9.65–16.35) | 0.048 |
| Urea nitrogen, mmol/L | 1.43–7.14 | 4.25 (3.73–4.97) | 5.14 (4.68–6.91) | 0.012 |
| Creatinine, mmol/L | 44–97 | 65.61 ± 15.63 | 77.63 ± 23.97 | 0.060 |
| UA, μmol/L | 170–390 | 276.96 ± 84.70 | 276.37 ± 147.67 | 0.987 |
| Glucose, mmol/L | 3.89–6.11 | 5.40 (4.82–5.95) | 5.79 (5.14–8.33) | 0.187 |
| Inflammatory markers | ||||
| ESR, mm/h | 0–20 | 26.50 (7.00–45.50) | 52.00 (20.00–86.50) | 0.050 |
| Myocardial injury markers | ||||
| CK, U/L | 25–200 | 76.20 (49.13–104.83) | 54.00 (36.50–117.90) | 0.290 |
| LDH, U/L | 100–240 | 191.90 (164.25–230.43) | 219.00 (139.00–322.60) | 0.345 |
| Blood coagulation | ||||
| Prothrombin time, s | 10.0–13.5 | 12.25 (10.75–14.55) | 15.20 (11.40–16.35) | 0.043 |
| D-dimer, mg/L | 0–0.55 | 0.23 ± 0.17 | 0.42 ± 0.21 | 0.006 |
| Treatment | ||||
| low-dose corticosteroids | 6 (13.04%) | 1 (11.11%) | 1.000 | |
| Hospital period (d) | 15.50 (10.00–18.00) | 17.00 (11.50–19.50) | 0.600 |
Data are expressed as mean± SD, median (IQR) and No. (%). Comparisons were determined by Student's test, Mann-Whitney U test or χ2 test as appropriate.
Abbreviations: NLR, Neutrophil-lymphocyte ratio. ALT, Alanine aminotransferase. AST, Aspartate aminotransferase. TP, Total protein. GGT, Gamma-Glutamyl Transferase. UA, Uric acid. TG, Triglyceride. HDL, High-density lipoprotein. ESR, Erythrocyte sedimentation rate. CK, Creatine kinase. LDH, Lactate dehydrogenase.