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Inhibitory effect of remdesivir-berberine combined treatment against SARS-CoV-2 in vitro. For each experimental condition, IC50, CC50 and the corresponding SI values are listed.
| Combination treatment | IC50 (M) | CC50 (M) | SI |
|---|---|---|---|
| Remdesivir | 0.987 | 275 | 278.62 |
| Remdesivir + Berberine 12.5 M |
0.409 | 264 | 645.47 |
| Berberine | 10.577 | > 400 | > 37.84 |
| Berberine + Remdesivir 0.625 M |
6.95 | > 57.55 | |
| Berberine + Remdesivir 2.5 M |
8.237 | > 48.56 |
