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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Cell Rep. 2020 Feb 4;30(5):1385–1399.e7. doi: 10.1016/j.celrep.2020.01.020

Figure 7. Model Depicting Genome Stabilizing Functions of Mre11 at Oncogene-Induced Transcription-Replication Conflicts.

Figure 7.

Mre11 dysfunction during oncogenic breast neoplasia results in accumulation of R-loops, replication-associated DSBs, under-repllcated DNA, an enrichment of genomic deletions, and uncontrolled proliferation. See the Discussion for further details.