TABLE 1.

Clinical characteristics and treatment of 9 hematological patients with COVID‐19

	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7	Case 8	Case 9
Age (years)	53	57	45	64	31	17	30	68	50
Sex	Female	Male	Male	Male	Male	Male	Female	Female	Male
Hematological disease
Diagnosis	AA	AML‐M5	AML‐M5	AML‐M5	Ph+ B‐ALL	Ph+ B‐ALL	Ph‐like ALL	DLBCL	MM
Remission	No	Yes	Yes	No	Yes	Yes	No	Yes	Yes
Agranulocytosis	Yes	No	No	Yes	No	No	Yes	No	No
Time of last treatment	Within 1 mo	Within 1 mo	Within 1 mo	4 d ago	Duration	Within 1 mo	Duration	Within 1 mo	Within 3 mo
Last treatment regimen	CsA	Dec, HA	Dec, IA	Dec	Dasatinib	Dasatinib, VP	Sorafenib Venetoclax	R‐CHOP	BCMA‐CAR T cell
SARS‐CoV‐2
Associated transmission	Community	Hospital	Hospital	Hospital	Hospital	Hospital	Hospital	Community	Hospital
Clinical manifestation
Fever	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes
Fatigue	Yes	Yes	No	Yes	No	No	Yes	No	No
Dry cough	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes
Expectoration	No	Yes	Yes	Yes	No	No	Yes	No	Yes
Hemoptysis	Yes	No	Yes	No	No	No	No	No	No
Dyspnea	Yes	No	Yes	No	No	No	No	Yes	Yes
Diarrhea	No	No	No	No	Yes	No	Yes	No	No
Nausea and vomiting	No	No	No	No	No	No	Yes	No	No
Clinical classification	Moderate	Moderate	Moderate	Moderate	Moderate	Moderate	Moderate	Moderate	Critically
Nucleic acid and Ab testing
Throat swabs	Negative	Positive	Negative	Positive	Negative	Negative	Positive	Positive	Positive
Plasma (copies/mL)	ND	ND	1384	ND	250	116	ND	ND	5044
Ab	Positive	Positive	Negative	ND	Negative	Negative	ND	Negative	Negative
Therapy
Antiviral	Arbidol	Arbidol Lopinavir Ritonavir	Arbidol	Arbidol	Arbidol Lopinavir Ritonavir	Arbidol Lopinavir Ritonavir	Arbidol Lopinavir Ritonavir	Arbidol	Arbidol Lopinavir Ritonavir
Antibiotics	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes
Antifungal	Yes	Yes	Yes	Yes	No	Yes	Yes	No	Yes
Immunoglobulin	Yes	Yes	No	Yes	No	No	Yes	No	Yes
Corticosteroids	No	No	No	No	Yes	Yes	No	No	Yes
Oxygen therapy	IMV	No	Nasal catheter	NMV	Nasal catheter	Nasal catheter	Nasal catheter	Nasal catheter	NMV
Clinical outcomes
Outcome	Death	Stay in hospital	Discharged from hospital	Death	Discharged from hospital	Discharged from hospital	Death	Discharged from hospital	Death
Cause of death	Septicopyemia	NA	NA	Septic shock	NA	NA	Intracranial invasion	NA	Respiratory failure

Abbreviations: Ab, antibody; AA, aplastic anemia; AML‐M5, acute monocytic leukemia; B‐ALL, acute B lymphoblastic leukemia; BCMA‐CAR, B‐cell maturation antigen chimeric antigen receptor; CsA, cyclosporine A; Dec, decitabine; DLBCL, diffuse large B‐cell lymphoma; HA, homoharringtonine, cytarabine; IA, idarubicin, cytarabine; IMV, invasive mechanical ventilation; MM, multiple myeloma; NA, not available; ND, not done; NMV, noninvasive mechanical ventilation; R‐CHOP, rituximab, cyclophosphamide, epirubicin, vindesine, prednisolone; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2; VP, vindesine, prednisolone.