Table 2.
Maternal presentation of COVID‐19, and maternal and obstetric outcomes, stratified by SARS‐CoV‐2 RT‐PCR result and symptomatic status
|
SARS‐CoV‐2 RT‐PCR positive |
SARS‐CoV‐2 RT‐PCR negative |
P value | ||
|---|---|---|---|---|
| Symptomatic | Asymptomatic | |||
| n = 15 | n = 55 | n = 605 | ||
| Maternal presentation at admission | ||||
| Temperature (°C), mean (SD) | 37.0 (0.7) | 36.8 (0.3) | – | 0.17 |
| Heart rate (beats per minute), mean (SD) | 91.8 (11.1) | 88.4 (17.3) | – | 0.47 |
| Respiratory rate (breaths per minute), mean (SD) | 19.5 (5.5) | 18.0 (2.0) | – | 0.11 |
| Oxygen saturation (%), median (IQR) | 99.0 (97.0–100.0) | 99.0 (98.0–100.0) | – | 0.60 |
| White blood cell count, mean (SD) | 8.8 (2.4) | 9.0 (3.1) | – | 0.78 |
| Platelet count, mean (SD) | 231.8 (101.5) | 207.9 (72.4) | – | 0.30 |
| Maternal outcomes | ||||
| Need for respiratory support, n (%) | 2 (13.3) | 1 (1.8) | – | 0.11 |
| Abnormal chest imaging findings, n (%) | 3 (20.0) | 2 (3.6) | – | 0.062 |
| ICU admission, n (%) | 1 (6.7) | 0 (0.0) | – | 0.21 |
| Treatment administered, n (%) | ||||
| Hydroxychloroquine | 2 (13.3) | 3 (5.5) | – | 0.45 |
| Azithromycin | 0 (0.0) | 2 (3.6) | – | |
| None | 13 (86.7) | 50 (90.9) | – | |
| Obstetric outcomes | ||||
| Live birth, n (%) | 15 (100.0) | 54 (98.2) | 599 (99.0) | 0.54 |
| Preterm birth <37 weeks of gestation, n (%) | 2 (13.3) | 9 (16.4) | 57 (9.4) | 0.16 |
| Mode of delivery,* n (%) | ||||
| Vaginal delivery | 8 (53.3) | 30 (54.5) | 417 (68.9) | 0.044 |
| Caesarean delivery | 7 (46.7) | 25 (45.5) | 187 (30.9) | |
| Indication for caesarean delivery, n (%) | ||||
| Nonreassuring fetal status | 1 (6.7) | 3 (5.5) | 23 (3.8) | 0.83 |
| Labour indications | 2 (13.3) | 7 (12.7) | 33 (5.5) | |
| Scheduled repeat | 2 (13.3) | 6 (10.9) | 74 (12.2) | |
| Multiple gestation | 0 (0.0) | 2 (3.6) | 11 (1.8) | |
| Malpresentation | 0 (0.0) | 1 (1.8) | 13 (2.1) | |
| Other | 2 (13.3) | 6 (10.9) | 33 (5.5) | |
| Multiple gestation, n (%) | 0 (0.0) | 4 (7.3) | 15 (2.5) | 0.12 |
| Intrapartum fever,** n (%) | 3 (27.3) | 4 (9.5) | 38 (8.1) | 0.093 |
| Postpartum haemorrhage >1000 ml, n (%) | 1 (6.7) | 2 (3.6) | 38 (6.3) | 0.74 |
| Postpartum fever, n (%) | 5 (33.3) | 3 (5.5) | 17 (2.8) | <0.001 |
| Aetiology of postpartum fever, n (%) | ||||
| Endometritis | 0 (0.0) | 0 (0.0) | 8 (1.3) | <0.001 |
| COVID‐19 | 3 (20.0) | 1 (1.8) | 0 (0.0) | |
| Endometritis or COVID‐19, cannot differentiate | 2 (13.3) | 2 (3.6) | 1 (0.2) | |
| Other | 0 (0.0) | 0 (0.0) | 8 (1.3) | |
| Length of stay (days), median (IQR) | 3.6 (2.1) | 2.6 (1.1) | 2.5 (1.1) | <0.001 |
| Postpartum readmission, n (%) | 1 (6.7) | 2 (3.6) | 9 (1.5) | 0.019 |
*
One woman who was SARS‐CoV‐2 negative had a dilatation and evacuation <24 weeks of gestation.
**
Denominator is women who laboured – 11 women with symptomatic COVID‐19, 42 women with asymptomatic COVID‐19 and 469 women without COVID‐19.