Table 4.
Placental pathological findings, stratified by SARS‐CoV‐2 status
| SARS‐CoV‐2 RT‐PCR positive | SARS‐CoV‐2 RT‐PCR negative | P value | |
|---|---|---|---|
| n = 29* | n = 106** | ||
| Fetal vascular malperfusion, n (%) | |||
| Absent | 15 (51.7) | 94 (88.7) | <0.001 |
| Present | 14 (48.3) | 12 (11.3) | |
| Maternal vascular malperfusion, n (%) | |||
| Absent | 21 (72.4) | 73 (68.9) | 0.82 |
| Present | 8 (27.6) | 33 (31.1) | |
| Histological evidence of chorioamnionitis, n (%) | |||
| None | 26 (89.7) | 90 (84.9) | 0.92 |
| Maternal response | 1 (3.4) | 8 (7.5) | |
| Fetal response | 0 (0.0) | 1 (0.9) | |
| Maternal and fetal response | 2 (6.9) | 7 (6.6) | |
| Chronic villitis, n (%) | |||
| Absent | 24 (82.8) | 93 (87.7) | 0.36 |
| Low‐grade | 2 (6.9) | 9 (8.5) | |
| High‐grade | 3 (10.3) | 4 (3.8) | |
| Meconium staining of placenta, n (%) | |||
| Absent | 11 (37.9) | 73 (68.9) | 0.004 |
| Present | 18 (62.1) | 33 (31.1) | |
| Umbilical cord abnormalities, n (%) | |||
| Absent | 28 (96.6) | 89 (84.0) | 0.12 |
| Present | 1 (3.4) | 17 (16.0) | |
| Chorangiosis, n (%) | |||
| Absent | 29 (100.0) | 105 (99.1) | 1.00 |
| Focal | 0 (0.0) | 1 (0.9) | |
| Other placental abnormalities, n (%) | |||
| None | 26 (89.7) | 96 (90.6) | 1.00 |
| Other | 3 (10.3) | 10 (9.4) | |
*
Data are derived from 28 deliveries, including one delivery of a twin gestation, resulting in 29 placentas evaluated.
**
Data are derived from 99 deliveries, including six deliveries of twin gestations and one delivery of a triplet gestation, resulting in 106 placentas evaluated.