Table 1.

The main features of the included studies for anti‐SARS‐CoV‐2 IgG/IgM in the diagnosis of COVID‐19

No.	Author	Number (cases/controls)	Daysa	Study type	Cases	Controls	Method
1	Dohla et al 7	22/27	19 (IQR: 15‐24)	Prospective	PCR+	PCR−	GICA
2	Hoffman et al 8	28/125	Range 9‐29	Retrospective	PCR+	Healthy persons	GICA
3	Infantino et al 9	30/63	12 (range 8‐17)	Retrospective	PCR+	Patients without SARS‐CoV‐2 and healthy persons	CLIA
4	Jin et al 10	27/33	16 (IQR: 9‐20)	Retrospective	PCR+	PCR−	CLIA
5	Li et al 3	397/128	Range 8‐33	Retrospective	PCR+, clinical feathers	Patients without SARS‐CoV‐2	GICA
6	Liu et al 11	214/100	15 (range 0‐55)	Retrospective	PCR+	PCR−	ELISA
7	Pan et al 12	86/22	Range 0‐34	Retrospective	PCR+	PCR−	GICA
8	Qu et al 13	41/38	Range 3‐43	Retrospective	PCR+	Patients without SARS‐CoV‐2	CLIA
9	Shen et al 14	97/53	Range 0‐28	Retrospective	PCR+	PCR− and healthy persons	GICA
10	Spicuzza et al 15	23/14	Range 3‐34	Retrospective	PCR+	PCR−	GICA
11	Xiang et al 16	90/60	Range 13‐29	Retrospective	PCR+ and clinical feathers	Healthy persons	ELISA
12	Bao et al 17	179/100	37 (range, 9‐62)	Retrospective	PCR+	Healthy persons	GICA
13	Deng et al 18	32/44	⋯	Retrospective	PCR+	PCR−	GICA
14	Li et al 19	116/134	⋯	Retrospective	PCR+	PCR−	CLIA
15	Liang et al 21	236/59	⋯	Retrospective	PCR+	Healthy persons	GICA
16	Li et al 20	25/60	Convalescence	Retrospective	PCR+	PCR−	CLIA
17	Luo et al 22	101/54	⋯	Retrospective	PCR+ and clinical feathers	PCR−	GICA
18	Tang et al 23	113/27	25 (range, 3‐47)	Retrospective	PCR+ and clinical feathers	Patients without SARS‐CoV‐2	CLIA
19	Xiong et al 24	97/100	⋯	Retrospective	PCR+	PCR−	CLIA and ELISA
20	Xu et al 25	205/79	⋯	Retrospective	PCR+ and clinical feathers	Patients without SARS‐CoV‐2	CLIA
21	Zhang et al 26	105/138	⋯	Retrospective	PCR+ and clinical feathers	PCR− and healthy persons	GICA
22	Zheng et al 27	25/20	⋯	Retrospective	PCR+	PCR−	CLIA and GICA

Note: Only the first author of each study is given.

Abbreviations: PCR+, PCR positive; PCR−, PCR negative; GICA, gold immunochromatography assay; CLIA, chemiluminescence immunoassay; ELISA, enzyme‐linked immunosorbent assay; IQR, interquartile range; IgG, immunoglobulin G; IgM, immunoglobulin M.

^aDays between the collection of blood samples and the symptom onset.