TABLE 2.
Genomic features for cognitive frailty Model I and Model II
| Model I | Gene | SNP‐associated allele | Chromosome | xgboost rank importance | β | SE | P‐value |
|---|---|---|---|---|---|---|---|
| CD33 | rs3865444_A | 19 | 0.0036 | 0.62 | 0.28 | .03 | |
| ACOT11 /LOC105378734 | rs12752888_C | 1 | 0.0035 | ‐0.47 | 0.18 | <.01 | |
| MTRR | rs1801394_G | 5 | 0.0029 | 0.80 | 0.23 | <.01 | |
| DAB1 | rs1539053_A | 1 | 0.0017 | 0.50 | 0.20 | .01 | |
| MMP3 | rs948399_C | 11 | 0.0011 | 0.41 | 0.17 | .01 | |
| Model II | |||||||
| APOE | rs429358_C | 19 | 0.0042 | ‐0.59 | 0.23 | .01 | |
| ACOT11 / LOC105378734 | rs12752888_C | 1 | 0.0024 | ‐0.37 | 0.15 | .01 | |
| TOMM40 | rs8106922_G | 19 | 0.0011 | ‐0.31 | 0.16 | .05 | |
| SLCO1B1 | rs4363657_C | 12 | 0.0008 | 0.38 | 0.16 | .02 | |
| MMP3 | rs948399_C | 11 | 0.0003 | 0.29 | 0.15 | .05 |
Notes: Statistically significant genes are shown in association with cognitive frailty compared to healthy adults Models I and II use Mini‐Mental State Examination (MMSE) and Trail Making Tests (TMT) parameters, respectively, to define cognitive frailty. Bold text indicates the closest gene to an intergenic single nucleotide polymorphism (SNP). The xgboost rank importance: xgboost ranks each SNP by level of importance based on its contribution to the model. Beta coefficients, standard error (SE), and P‐values for each SNP were derived from subsequent logistic regression analysis after xgboost ranking.